Senolytics in Disease, Ageing and Longevity by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030449032
Publisher: Springer International Publishing

6.3 The Senescent Surfaceome

In the search for better markers of senescence, the profile of proteins present on the surface of these cells, known as the senescent surfaceome, has emerged as a potentially interesting alternative (Table 6.1). In general, the surfaceome could be defined as the panel of all plasma membrane proteins of a given cell type that exhibit at least one amino acid residue at the extracellular space. The majority of the human surfaceome consist of all types of transmembrane proteins, single and or polytopic ɑ-helical or β-sheet transmembrane proteins (Bausch-Fluck et al. 2018). Like other senescent markers, those in the surfaceome are expressed varyingly but consistently across different tissues and conditions and are unlikely to be universal. One of the most interesting features of the novel markers of senescence present in the senescent surfaceome are their extracellular epitopes, which could be used for targeted therapies, as discussed below.Table 6.1Main validated members of the senescent surfaceome

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